Protein Details: Voltage-gated Potassium channel-interacting protein 4

Protein ID

ICDB_Pro_1424

Protein Name

Voltage-gated Potassium channel-interacting protein 4

Gene Name

Kcnip4; Kchip4

Organism

Rattus norvegicus (Rat)

Length

250 amino acids

AlphaFoldDB

AF-Q99MG9-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels; such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane; gating characteristics; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner

Sequence

MNVRRVESISAQLEEASSTGGFLYAQNNTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

133;135;137;144;169;171;173;175;180;217;219;221;228

Disease

Location

Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells.

DOI ID

10.1111/j.1469-7793.2001.0119b.x; 10.1073/pnas.022509299; 10.1074/jbc.m200897200; 10.1523/jneurosci.0776-04.2004; 10.1021/bi802316m; 10.1038/ncomms1871; 10.1074/jbc.m114.563452

RefSeq

NP_852030.1 [Q99MG9-1]; XP_017454578.1 [Q99MG9-2]